Humans normally have 46 chromosomes in each cell, divided into 23
pairs. Two copies of chromosome 10, one copy inherited from each parent,
form one of the pairs. Chromosome 10 spans more than 135 million DNA
building blocks (base pairs) and represents between 4 and 4.5 percent of
the total DNA in cells.
Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 10 likely contains 700 to 800 genes that provide instructions for making proteins. These proteins perform a variety of different roles in the body.
Genes on chromosome 10 are among the estimated 20,000 to 25,000 total genes in the human genome.
Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 10 likely contains 700 to 800 genes that provide instructions for making proteins. These proteins perform a variety of different roles in the body.
Genes on chromosome 10 are among the estimated 20,000 to 25,000 total genes in the human genome.
How are changes in chromosome 10 related to health conditions?
Many genetic conditions are related to changes in particular genes on chromosome 10.
This list of disorders associated with genes on chromosome 10 provides links to additional information.
Changes in the structure or number of copies of a chromosome can also cause problems with health and development. The following chromosomal conditions are associated with such changes in chromosome 10.
Changes in the structure or number of copies of a chromosome can also cause problems with health and development. The following chromosomal conditions are associated with such changes in chromosome 10.
- cancers
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Changes in the number and structure of chromosome 10 are associated
with several types of cancer. For example, a loss of all or part of
chromosome 10 is often found in brain tumors called gliomas,
particularly in aggressive, fast-growing gliomas. The association of
cancerous tumors with a loss of chromosome 10 suggests that some genes
on this chromosome play critical roles in controlling the growth and
division of cells. Without these genes, cells could grow and divide too
quickly or in an uncontrolled way, resulting in cancer. Researchers
are working to identify the specific genes on chromosome 10 that may be
involved in the development and progression of gliomas.
A complex rearrangement (translocation) of genetic material between chromosomes 10 and 11 is associated with several types of blood cancer known as leukemias. This chromosomal abnormality is found only in cancer cells. It fuses part of a specific gene from chromosome 11 (the MLL gene) with part of another gene from chromosome 10 (the MLLT10 gene). The abnormal protein produced from this fused gene signals cells to divide without control or order, leading to the development of cancer.
- Crohn disease
-
Variations in a particular region of chromosome 10 have been
associated with the risk of developing Crohn disease. These genetic
changes are located on the long (q) arm of the chromosome at a position
designated 10q21.1. Researchers refer to this part of chromosome 10 as a
"gene desert" because it contains no known genes. However, it may
contain stretches of DNA that help regulate nearby genes such as ERG2.
This gene has a potential role in immune system function, and
researchers are interested in studying the gene further to determine
whether it is associated with Crohn disease risk.
- other chromosomal conditions
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Other changes in the number or structure of chromosome 10 can have a
variety of effects. Intellectual disability, delayed growth and
development, distinctive facial features, and heart defects are common
features. Changes to chromosome 10 include an extra piece of the
chromosome in each cell (partial trisomy), a missing segment of the
chromosome in each cell (partial monosomy), and an abnormal structure
called a ring chromosome 10. Ring chromosomes occur when a chromosome
breaks in two places and the ends of the chromosome arms fuse together
to form a circular structure. Rearrangements (translocations) of
genetic material between chromosomes can also lead to extra or missing
material from chromosome 10.
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